Xiangdong Li Selected Research

tongxinluo

1/2022	Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway.
1/2022	Sequential transplantation of exosomes and mesenchymal stem cells pretreated with a combination of hypoxia and Tongxinluo efficiently facilitates cardiac repair.
8/2020	Tongxinluo attenuates oxygen-glucose-serum deprivation/restoration-induced endothelial barrier breakdown via peroxisome proliferator activated receptor-α/angiopoietin-like 4 pathway in high glucose-incubated human cardiac microvascular endothelial cells.
1/2020	China Tongxinluo Study for myocardial protection in patients with Acute Myocardial Infarction (CTS-AMI): Rationale and design of a randomized, double-blind, placebo-controlled, multicenter clinical trial.
1/2020	Cardiomyocyte-derived small extracellular vesicles can signal eNOS activation in cardiac microvascular endothelial cells to protect against Ischemia/Reperfusion injury.
1/2018	Tongxinluo attenuates reperfusion injury in diabetic hearts by angiopoietin-like 4-mediated protection of endothelial barrier integrity via PPAR-α pathway.
1/2016	Tongxinluo modulates cytokine secretion by cardiac microvascular endothelial cells in ischemia/reperfusion injury.
1/2015	Cardiac microvascular barrier function mediates the protection of Tongxinluo against myocardial ischemia/reperfusion injury.
8/2014	Induction of autophagy by Tongxinluo through the MEK/ERK pathway protects human cardiac microvascular endothelial cells from hypoxia/reoxygenation injury.

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Xiangdong Li Research Topics

Disease

34	Neoplasms (Cancer) 09/2022 - 04/2004
19	Infections 03/2022 - 05/2009
9	Myocardial Infarction 01/2022 - 01/2015
6	Hypoxia (Hypoxemia) 01/2022 - 08/2014
6	Inflammation (Inflammations) 01/2022 - 03/2006
5	Carcinogenesis 10/2022 - 05/2012
5	Carcinoma (Carcinomatosis) 07/2021 - 04/2004
5	Reperfusion Injury 08/2020 - 01/2015
4	Urinary Bladder Neoplasms (Bladder Cancer) 09/2022 - 08/2018
4	Ischemia 01/2022 - 01/2015
4	Virus Diseases (Viral Diseases) 01/2021 - 06/2017
4	Neoplasm Metastasis (Metastasis) 11/2020 - 07/2015
4	Porcine Reproductive and Respiratory Syndrome (PRRS) 04/2020 - 07/2015
4	Myocardial Ischemia (Ischemic Heart Diseases) 01/2020 - 01/2015
3	Hemorrhage 01/2022 - 01/2018
3	Infarction (Infarctions) 01/2022 - 01/2018
3	Pituitary Neoplasms (Pituitary Adenoma) 01/2021 - 03/2004
3	Coronary Artery Disease (Coronary Atherosclerosis) 01/2021 - 01/2018
3	Zika Virus Infection 10/2018 - 12/2016
3	Breast Neoplasms (Breast Cancer) 01/2018 - 02/2010
2	Fibrosis (Cirrhosis) 05/2022 - 12/2021
2	Lung Neoplasms (Lung Cancer) 01/2022 - 02/2013
2	Wounds and Injuries (Trauma) 04/2021 - 01/2019
2	Coronary Disease (Coronary Heart Disease) 01/2021 - 01/2015
2	Pulmonary Arterial Hypertension 01/2021 - 11/2020
2	Lymphatic Metastasis 11/2020 - 01/2018
2	Osteoblastoma 05/2020 - 04/2008
2	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 11/2015
2	Glioma (Gliomas) 09/2017 - 03/2013
2	Ebola Hemorrhagic Fever 01/2017 - 10/2016
2	Infertility (Sterility) 06/2014 - 03/2006
2	Male Infertility (Male Sterility) 06/2014 - 03/2006
2	Ovarian Neoplasms (Ovarian Cancer) 03/2014 - 01/2012
2	Granulosa Cell Tumor 03/2014 - 01/2012
2	Urinary Bladder Neck Obstruction (Bladder Neck Obstruction) 03/2011 - 02/2010
2	Gynecomastia 02/2010 - 03/2004
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 10/2022
1	Multiple Abnormalities 07/2022
1	Diabetes Mellitus 01/2022
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2022

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 10/2022 - 05/2009
12	VaccinesIBA 01/2021 - 01/2015
9	tongxinluoIBA 01/2022 - 08/2014
8	MicroRNAs (MicroRNA)IBA 01/2021 - 03/2013
8	Estrogens (Estrogen)FDA Link 06/2014 - 03/2004
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2014
5	Aromatase (CYP19)IBA 06/2014 - 03/2004
4	Small Interfering RNA (siRNA)IBA 09/2022 - 01/2015
4	Pharmaceutical PreparationsIBA 01/2022 - 04/2015
4	Messenger RNA (mRNA)IBA 07/2021 - 04/2004
4	CytokinesIBA 01/2021 - 01/2016
4	LH Receptors (LH Receptor)IBA 03/2014 - 04/2004
4	AndrogensIBA 02/2013 - 03/2004
3	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2018
3	InterferonsIBA 01/2021 - 10/2016
3	InflammasomesIBA 01/2021 - 05/2016
3	Long Noncoding RNAIBA 01/2021 - 01/2018
3	MelatoninIBA 11/2020 - 05/2016
3	CholesterolIBA 01/2020 - 02/2013
3	Estrogen ReceptorsIBA 01/2019 - 03/2006
3	Glycoproteins (Glycoprotein)IBA 12/2017 - 04/2010
2	Therapeutic UsesIBA 01/2022 - 01/2012
2	Circular RNAIBA 01/2022 - 01/2021
2	Zona Pellucida GlycoproteinsIBA 01/2022 - 03/2014
2	SolutionsIBA 08/2021 - 10/2017
2	Biological ProductsIBA 07/2021 - 01/2017
2	AntioxidantsIBA 01/2021 - 12/2019
2	SteroidsIBA 11/2020 - 02/2013
2	EnzymesIBA 11/2020 - 03/2006
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 08/2020 - 01/2018
2	cadherin 5IBA 08/2020 - 01/2018
2	GTP-Binding Proteins (G-Protein)IBA 01/2019 - 04/2010
2	AntibodiesIBA 12/2017 - 05/2009
2	Cadherins (E-Cadherin)IBA 10/2016 - 07/2015
2	Tumor Viral Antigens (Large T Antigen)IBA 03/2014 - 01/2012
2	Luteinizing Hormone (Lutropin)FDA LinkGeneric 03/2014 - 04/2013
2	Peptides (Polypeptides)IBA 03/2014 - 04/2004
2	Inhibins (Inhibin)IBA 03/2014 - 01/2012
2	GonadotropinsIBA 03/2014 - 04/2013
1	TubulinIBA 09/2022
1	Carrier Proteins (Binding Protein)IBA 09/2022
1	Immunoglobulins (Immunoglobulin)IBA 09/2022
1	LipidsIBA 07/2022
1	trimethyloxamine (trimethylamine N-oxide)IBA 05/2022
1	AerosolsIBA 03/2022
1	Viral ProteinsIBA 01/2022
1	Cetuximab (Erbitux)FDA Link 01/2022
1	ImmunosorbentsIBA 01/2022
1	Complement System Proteins (Complement)IBA 01/2022

Therapy/Procedure

8	Therapeutics 09/2022 - 04/2007
4	Immunotherapy 01/2022 - 01/2012
4	Drug Therapy (Chemotherapy) 01/2020 - 04/2015
4	Limb Salvage 10/2017 - 12/2012
3	Chinese Traditional Medicine (Traditional Chinese Medicine) 08/2020 - 01/2020
2	Transplantation 01/2022 - 04/2008
2	Ligation 12/2021 - 08/2016
2	Extracorporeal Membrane Oxygenation 11/2021 - 02/2021
2	Castration 01/2020 - 04/2013
2	Nephroureterectomy 01/2020 - 11/2018
2	Prostheses and Implants (Prosthesis) 06/2013 - 12/2012